What is Amoxicillin?
Amoxicillin is an antibacterial drug which belongs to a group of penicillin. The drug has a broad action, it means it acts on various types of bacteria and pathogenic organisms.
As all penicillin agents, Amoxicillin has many peculiarities which distinguish it against other groups of the antibiotics:
- A low toxicity and a high index of the pharmacological safety;
- A broad range of doses for children and adults;
- A fast therapeutic effect.
Besides positive characteristics, Amoxicillin has many drawbacks:
- Polyvalent allergy between penicillin antibiotics and some cephalosporin’s. If a patient has an allergy to Ampicillin or another drug in this group, the same reaction will be to the use of Amoxicillin.
- Amoxicillin is affected under the action of beta-lactamase. Due to this, the spectrum of the pharmacological action of the antibiotic gets narrow gradually.
Amoxicillin shows its pharmacological activity as to the following types of bacteria:
- Aerobic gram-positive activators: Staphylococcus spp.
- Aerobic gram negative activators: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp.
Amoxicillin is released in many medical forms, and it allows using the medication during infections of any site. It quickly penetrates into liquids and tissues of the body, and is accumulated in places where the inflammatory process is most apparent.
The most demanded Amoxicillin pills are 250 mg and 500 mg. The pills are quickly absorbed into the intestine, does not cause a stomach disorder, and the bioavailability of the active ingredients is more than 95% during the peroral use.
The acid-resistance of amoxicillin is higher than in other penicillin medications, and that is why the pills are not affected under the action of the gastric juice and may be used both before, and after meals.
To treat infectious processes of the average severity, the long lasting courses of Amoxicillin are not required. 5-7 days are enough for a complete reduction of the disease symptoms. The dosing is based on many factors, from patient’s age and the body mass, on out to the severity of an infection and its site.
Amoxicillin may be taken during inflammatory processes of the infectious origin:
- Organs of the respiratory system (upper and lower parts): pneumonia, bronchitis, pharyngitis, whooping cough, and others.
- ENT-organs: otitis media, sinusitis, etc.
- Organs of the urinary tract, including those with genital infections: urethritis, prostatitis, pyelonephritis, cystitis.
- Organs of the gastrointestinal tract and abdominal cavity: paratyphoid, stomach and duodenal ulcer, salmonellosis, cholecystitis.
- Skin and soft tissues, dental infections.
The treatment usually takes at least 2 days from the moment of removing all disease symptoms. If a visual diagnostics of the symptoms is questionable, the blood test is needed to detect an infection.
Amoxicillin 500 mg for infections: Pharmacological action
Amoxicillin 500 mg has a bactericidal method of the action as to bacteria. Any pathogenic flora has life cycles which are based on synthesizing of new cells with bacteria.
The principle of the pharmacological action of Amoxicillin consists in a destruction of the initial vital cycle of any pathogenic organism, i.e. it inhibits the synthesis of the cellular wall of bacteria.
Getting into the body, Amoxicillin is quickly absorbed from the GIT and penetrates into the blood flow. Going to the inflammation site, it is accumulated in the place of the infection development and penetrates inside the cells. Due to blocking of the synthesis of peptidoglycan (the main ingredient of the cellular wall), Amoxicillin affects the natural vital cycle of flora and bacteria stop replicating. The rest organisms quickly die under the action of the immune systems of the body and the antibiotic.
A peculiarity of the therapeutic effect of Amoxicillin is a full destruction of bacteria cells, and they die. Having the bactericidal effect is especially important in the treatment of the weak patients, and during severe diseases such as sepsis, endocarditis, and others, when the body is not able to cope with an infection. A probability of a relapse of the infection is close to zero after the complete recovery.
Amoxicillin acts only on the pathogenic cells and does not inhibit the activity of the good flora.
There is a direct dependence between a dose and a concentration of the ingredient in the body, i.e. the increase of the dose by two times leads to the increase of the ingredient concentration by two times. It means that a reaction to the changed dose may be instant, and therefore patients are usually prescribed a minimal dose with the next increase in case of the weak therapeutic effect.
A period of achieving the maximal concentration of Amoxicillin is about 1-2 hours after the use of the single peroral dose. It means that the antibacterial action will begin in 2 hours, and the improvement of the patient’s state will occur rather quickly.
Amoxicillin is mostly accumulated in the lungs, kidneys, mucosa of the respiratory system, urine, and in the plasma. That is why, the highest effect is achieved in the treatment of the respiratory and urinary system diseases.
The intensity of the pharmacological action of Amoxicillin does not depend on a type of the pathogenic flora. If bacteria are vulnerable to the action of the antibiotic, the therapeutic effect will be maximal.
If the pathogenic flora releases beta-lactamases which affect Amoxicillin, a combined option of the antibiotic (Amoxicillin and clavulanic acid) is recommended. The additional ingredient increases the vulnerability of organisms and the efficiency of the penicillin antibiotic.
In case of severe infectious processes, a combined therapy helps to achieve faster results. As Amoxicillin is a bactericidal antibiotic, its use is allowed only with the drugs of the identical mechanism of the action. In this case, a synergetic effect will be achieved.
If Amoxicillin is taken with bacteriostatic antibiotics, the effect is significantly reduced because these medications neutralize the effect of each other.
But even during monotherapy with a proper dose, Amoxicillin gives good results and completely reduces an infectious-inflammatory process within a week.
Who can and can’t take Amoxicillin?
As Amoxicillin has a high index of the pharmacological safety, it is allowed for all patients. It is the antibiotic of a choice in the treatment of the infectious diseases in children. It is not toxic for the child’s body and is quickly excreted even by newborn babies (within 3-4 hours after the use).
Amoxicillin may be taken by pregnant women if a potential benefit from the treatment is higher than the potential risk for a fetus. During the clinical studies with pregnant women, it has found out that the use of Amoxicillin in the first term of pregnancy does not influence on the course of pregnancy and labors. A risk of deficiencies does not increase 2 percent out of 100.
However, refuse from Amoxicillin during lactation. The antibiotic penetrates into the breast-milk, and then it goes to the baby and the drug may be accumulated in the baby’s body during the frequent breastfeeding. As a result, a newborn may have an allergic reaction or other side effects. That is why, the breast-feeding should be stopped in case of an urgent need to take amoxicillin.
There are no age restrictions for the use Amoxicillin as well. Old people over 70 may take the drug if they do not have contraindications.
As about 80% of Amoxicillin is excreted by means of kidneys, patients with renal failure should be careful. consult a doctor during this pathology, and if creatinine clearance is too low, a patient may need a decreased daily dose, the increase of the interval between the use of the pills, or a refuse from the use of Amoxicillin.
If severe dysfunctions of kidneys, the speed of half-life of Amoxicillin may grow from 2 hours to 8-9 hours. And the accumulation of the excessive parts of the antibiotic may cause an overdose and adverse effects.
Amoxicillin is contraindicated patients with the following pathologies:
- Acute state of an allergic diathesis;
- Acute bronchial asthma;
- Pollen disease;
- Hepatic failure;
- Acute colitis or bleedings from the GIT during the attack of the gastric ulcer.
If a patient has had an allergy to any drug of penicillin agent, cephalosporin, carbapenems, the use of Amoxicillin is prohibited. In 99% of cases, an allergic reaction will begin after the use of Amoxicillin.
The contraindications include not only chronic pathological disorders which may become acute during the use of the antibiotic, but also various medical interactions. There are medications that are incompatible with Amoxicillin, and if you take them, it is not recommended to start the therapy. These medications are antacids, allopurinol, and methotrexate.
Women taking birth control pills should be very careful. Due to its pharmacokinetic peculiarities, Amoxicillin reduces the efficiency of the oral hormonal contraceptives. Therefore, it is recommended to use additional barrier methods during the treatment to protect against unwanted pregnancy.
How to buy Amoxil 250/500 mg online?
As any other strong antibiotic, Amoxicillin is for sale by a prescription in the city pharmacies. If you do not have a prescription, or it has been expired, you will not be able to get a pack with the pills and start the treatment.
Amoxicillin without prescription may be found only in the online pharmacy. It may be often found under the trade mark Amoxil 250 mg or Amoxil 500 mg.
In the online pharmacy, it is possible to find the required number of the pills at a reasonable price, and it is not obligatory to give the representatives of the pharmacy a prescription, medical questionnaires, or other medical papers. Of course, you should realize that buying Amoxil online, you need a professional medical consultation. In this case, a pharmacist of the online pharmacy will help you and answer any questions free of charge.
Amoxil online is for sale 24 hours. It is another advantage of the online pharmacies: they work without weekends, and an order may be placed at any time. The package will be sent to the indicated address within 24 hours by post or courier.
To buy Amoxil 250/500 mg online, it is necessary to decide on a number of the pills and way of the delivery. The order may be paid with the help of a bank card Visa, or MasterCard.
Buying Amoxil online, you can be confident in a quality of the pills. It is the same pills that are for sale in the pharmacies in the city. The pills are supplied directly from the manufacturer to the warehouse of the online pharmacy, and meet the international pharmaceutical standards.
Due to direct supplies of Amoxicillin, its cost is lower in the online pharmacy. The cost does not contain extra fee of the dealers who usually set a cost of every pill. Therefore, Amoxil online may be bought at a wholesale price of the manufacturer, by several times cheaper in comparison with the city pharmacies.